Oral stem cell therapy is a relatively new and still researched area, and its effects and indications are not yet fully established. Compared to intravenous or local injection of stem cell therapy, the absorption and mechanism of action of oral stem cells are subject to many limitations (e.g., how stem cells survive through the digestive tract and are absorbed). Currently, oral stem cell products are positioned more as health supplements rather than rigorous clinically proven treatments.
A colony of human embryonic stem cells
However, some diseases or health conditions are thought to potentially benefit from taking stem cells orally (based on theory or preliminary research), including the following:
1. Chronic inflammatory diseases
In 1986, according to the latest scientific research of the Anti-allergy Laboratory of the British Human Health Center, the reason why the human body has allergies is the lack of GS anti-allergy serum protein in the human body, which directly leads to the random invasion of external irritants into the respiratory mucosa, gastrointestinal mucosa, and skin connective tissues by mast cells and basophils and other lymphocytes, which react to form a series of allergic reactions such as itching, edema, congestion, and ulceration, rather than ordinary inflammation. After years of research, it was found that there is still a rich amount of GS anti-allergy serum protein in the placenta, which shows that this substance is not lacking at the beginning of human formation, and no allergic reactions will occur. It is just that with the formation and growth, this substance has gradually decreased. Therefore, as long as this substance is supplemented for the human body, it may be possible for the human body to get rid of the troubles of allergic diseases. This research caused a sensation in European countries at that time!
Stem cells are thought to have immunomodulatory effects and may be helpful in the following conditions:
1. Intestinal related diseases:
- Chronic enteritis (eg, Crohn's disease, ulcerative colitis)
- Irritable Bowel Syndrome (IBS)
2. Other chronic inflammations:Arthritis (such as rheumatoid arthritis)Skin inflammation (such as eczema, psoriasis)However, these effects mainly depend on whether the stem cells can survive and exert immunomodulatory functions, and the role of oral stem cells still needs more research to verify.
2. Anti-aging and regenerative medicine
Oral stem cells are often claimed by some health products and supplement companies to have the effect of delaying aging and promoting cell regeneration, including:
- Improve skin health (e.g. reduce wrinkles, increase elasticity)
- Promote tissue repair (such as wound healing, cartilage repair)
- Enhance energy metabolism or improve fatigue
These effects are usually based on bioactive substances (such as exosomes, cytokines) contained in stem cells, rather than the direct effects of the stem cells themselves.
3. Regulation of immune function
Taking stem cells by mouth may help modulate the immune system and help with the following conditions:
- Diseases related to immunosuppression (such as mild immune dysregulation or recovery of immune function after infection)
- Diseases related to immune overreaction (such as allergies, some autoimmune diseases)
However, current research focuses more on intravenous injection of stem cells, and the specific role of oral stem cells is still unclear.
4. Metabolic diseases
Some studies speculate that oral administration of stem cells may have potential benefits for metabolic diseases, such as:
- Diabetes: Exosomes from stem cells may improve insulin sensitivity.
- Obesity: Stem cells may modulate fat metabolism or reduce chronic inflammation.
These applications are still in the basic research stage and clinical evidence is limited.
5. Concentration and memory
There has been progress in the treatment of neurological diseases. It can effectively improve the signal reception of neuronal synapses in the brain. It can not only improve the memory loss of dementia, but also repair damaged neuron connections, which has been proven to effectively promote the regeneration of nerves in damaged areas. .
This is very important for the growth of memory stem cells, and the more memory stem cells there are, the better the memory. However, the repair of brain cells also requires the body to absorb enough high-quality protein, glucose and a variety of powerful oxidants to help each other.
6. Nervous system disease (hypothetical)
The neuroprotective and regenerative properties of stem cells may be helpful in neurodegenerative diseases such as:
- Mild Alzheimer's or Parkinson's disease
- Nerve repair after stroke recovery
But there is still no direct evidence whether oral stem cells can be absorbed through the intestines enough to affect the central nervous system.
7. Other possible applications
Some oral stem cell products are claimed to help the following conditions, but scientific support is limited:
- Digestive tract repair: such as gastric ulcers and impaired intestinal barrier function.
- Cardiovascular health: such as improving endothelial function.
- Sports recovery: such as accelerated repair after muscle injury.
Limitations and Challenges
It is important to note that oral stem cell therapy faces many challenges, including:
- Stem cell survival and absorption issues:
- It is still controversial whether stem cells can enter the blood circulation and play a role after being affected by gastric acid and digestive enzymes.
- The effects of stem cells may come more from the bioactive substances secreted by the cells than from the cells themselves.
- Lack of clinical evidence:
- At present, most oral stem cell products have not yet undergone rigorous clinical trials, and their effects are mostly based on theoretical speculation or animal experiment results.
- Market confusion and exaggerated propaganda:
- Many so-called “oral stem cell products” are actually stem cell extracts or nutritional supplements containing stem cell secretions and are not true active stem cells.
In conclusion
There is still much we don't understand about biochemical engineering, renewal and regeneration processes. Perhaps, only after cell biologists have uncovered all the mysteries of cells can we truly know what cell therapy is.
At present, the scope of application of oral stem cell therapy is still limited to preliminary research and has not yet become a mainstream medical treatment method. There may be potential benefit but more evidence is needed for:
- Chronic inflammatory disease
- Anti-aging and skin health
- Mild metabolic disorders or immune function modulation
If you want to use oral stem cells for treatment, be sure to consult a professional doctor and choose products that are scientifically proven. Meanwhile, for some diseases, intravenous or localized stem cell therapies remain more established options.
Nonetheless, one thing we do know is that fresh live placental cells can inject their vitality into degenerated old cells in the body, stimulating the renewal process of aging cells and restoring their operating efficiency, so that the body's organs can remain strong and active. In addition to its rejuvenating effect, worn out old cells will also take over the properties of young and healthy cells.
Many degenerative diseases such as arthritis, diabetes, Alzheimer's disease, osteoporosis, circulatory system disorders, menopause, phlegm and chronic fatigue can all benefit from the stimulation of fresh placenta live cells.
References
- Japanese stem cell researcher and a Nobel Prize laureate 山中 伸弥 https://en.wikipedia.org/wiki/Shinya_Yamanaka
- New opportunities for treating stroke – Cell therapy 2022-09-10 Dr. Liao Kexun, Dr. Huang Xiaomin
- The Secret of the Rich & Famous: Live Cell Therapy (Dr. Victor W S Chen, Malaysia), 2008
- Wikipedia - Cell therapy
- Stem cell therapy: a promising treatment, Cell therapy for intracerebral hemorrhage: five-year follow-up report. Exp Ther Med. 2016 Dec;12(6):3535-3540.
- Italian researchers have confirmed that amniotic fluid stem cell exosomes can protect nerve cells from apoptosis.
- In their research, American scholars found that placental interstitial cell exosomes can effectively restore blood flow to the injured side of the brain and thereby protect nerves. Am J Transl Res. 2018 Sep 15;10(9):2975-2989.
- Iranian researchers published in 2021 that amniotic mesenchymal stem cell supernatant can inhibit inflammation and protect nerve cells. It was confirmed that although the supernatant or exosomes do not contain cells, they contain complex components secreted by cells and have certain potential for nerve protection. World J Stem Cells. 2021 Aug 26;13(8):1151-1159.
- Kicht, 8, CHOH Young with HGH, Harper Collins 1997,
- Kenton, L, Age Power, Published by Random House 2002,
- Chen, V, hge Without Getting Old, Published by Ock Publications 2008,
- McArdle, W et al, Exercise Physiology, Publicned by lippincott Wiliam & Wikns
- 7. Chen.V. Staying Healthy, Staying Vital. Published by Oak Publications 2003.
- 8. Miller, J et al. The Facts of Life, Jonathan Cape Limited 1984.
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