In the 1930s, Swiss doctor Paul Niehans developed a living cell therapy called "Sheep Placenta Therapy". This therapy will dissolve living cells extracted from sheep embryos and sheep placentas in physiological saline and inject them into the patient, in order to achieve anti-aging effects on the skin.
It refers to isolating and removing cells from the patient's body, modifying them outside the body, and then reinjecting them as drugs.
Store peripheral blood stem cells to preserve healthy immune cells, such as NK cells, T cells, and DC cells when you are young. During storage, you need to inject leukocyte growth hormone for four consecutive days, and then collect stem cells on the fifth day. The process takes five to For six hours, the blood stem cells are frozen in liquid nitrogen at minus 196 degrees to stop aging; when needed, they are injected into the body again.
The generally discussed placenta does not necessarily refer to products extracted from sheep embryos. It has become a code name and a common name. It generally refers to a treatment method that mainly uses preparations produced from animal placenta as raw materials. The real injections may be obtained from other animal raw materials or other animal tissues. For example, glandular tissue or an adult organ. Japan was the first to develop and produce it, and the quality is also the highest. While factories in Japan and South Korea use human placenta to produce injectable drugs, they also use pig placenta to produce a series of oral placenta and cosmetic placenta. It is worth noting that this method currently requires professionals to perform and there are safety considerations.
Taiwan has approved the use of human exosomes (外泌體) as cosmetic raw materials. Currently, the industry development is still mainly focused on beauty. However, in the field of beauty, many clinical trials are underway around the world.
People who do not exercise have a higher risk of illness than those who exercise. This is mainly due to the low circulation capacity of stem cells. In terms of diet, eating more vegetables and fruits with bright colors and antioxidant capabilities can help stem cells become more active. Drinking more green tea can also achieve the same effect, and spending 15 to 20 minutes in the sun every day (excluding noon time) can also help the circulation of stem cells.
Oral Placenta Stem Cell
In areas other than beauty, many countries around the world allow placenta to be used for health purposes. Currently, there is still a lack of comprehensive clinical research and it cannot be used as a clinical medical drug. However, disease repair effects can be seen in users and some animals, such as brain nerve repair and neurodegeneration. As for various physical diseases, such as skin, anti-aging, and life extension, some effects have been seen in animals. However, whether this can be applied to humans requires further clinical trial results to determine its effectiveness.
Why placenta?
The placenta gives birth to life. The placenta is created for one purpose only, to protect and supply the nutrients needed for the growth of the fetus. It is a rich source of important nutrients and provides a combination of ingredients and enzymes needed for fetal growth.
Once the placenta has completed its mission, it has no other role to play. Modern medical research believes that the placenta contains protein, sugar, calcium, vitamins, immune factors, female hormones, progesterone, steroid hormones, gonadotropins, adrenocorticotropic hormone, etc. However, with the birth of stem cell technology and supercritical extraction technology, Primitive stem cells without estrogen or hormones can be extracted, greatly reducing the side effects of animal estrogen on the human body in the past.
Through freeze-drying technology, living cells can be preserved in liquid nitrogen, which was the only way in the past, and can maintain biological activity for up to 3-4 years. Freeze-drying technology stores stem cells in capsules, and emulsification technology allows larger particles of molecules to be absorbed through biliary chylomicrons, greatly reducing patients' reliance on expensive and time-consuming injections and surgeries. Sheep and deer proteins and placenta are more popular because they are more biocompatible with the human body and do not cause allergic reactions. Fetal stem cells have not yet developed antigenicity. In addition, you will find that there are no cases of foot and mouth disease, scrapie and BSE (mad cow disease) in New Zealand. Countries such as Switzerland and China are not immune to these diseases. The two countries are not geographically isolated. Livestock, birds and sheep affected by the disease can cross borders. They are not isolated countries like New Zealand.
◾️ Human placenta preparations, but the question is where do these placentas come from? Has it been tested for hepatitis, HIV and other viruses? Were these placentas illegally obtained from a third country? Will you sell your placenta to a manufacturer after delivery to make placenta products? I believe that these important issues must be considered and the use of human placenta should be avoided until the question of its origin has been satisfactorily answered.
Ziheche or Human placentophagy (紫河車)
Ziheche refers to the human placenta. It is red when it is first delivered and turns purple after a while, so it is called "Ziheche". In traditional Chinese medicine, it is considered to be beneficial to qi and blood, and tonifying the kidneys and essence. Modern medicine believes that it can promote the development of the breast, uterus, vagina, and testicles, and also promotes the thyroid gland. It is clinically used to treat uterine hypoplasia, uterine atrophy, myositis, functional amenorrhea, uterine bleeding, lactation deficiency, etc. All have significant curative effects, and are also effective against tuberculosis, bronchial asthma, anemia, etc. Grinding the powder orally or enema can prevent or alleviate symptoms.
In the Maremma region of Italy, there was a custom of adding human or animal placenta to food to help mothers produce milk after giving birth.
China is one of the few countries that advocates the consumption of human placenta. There are also different recipes in the market, including eating it raw. However, eating human placenta not only violates the taboo of cannibalism locally, but eating raw placenta may also bring the risk of contracting diseases. So far, It is not recognised by mainstream society. In 2015, Ziheche was removed from the 《Chinese Pharmacopoeia》.
Other alternatives
Human Growth Hormone (HGH)
Human growth hormone obtained from humans can be used to treat children with stunted growth. Unfortunately, some HGH have been infected with spongiform encephalopathy (mad cow disease in humans). Thus, synthetic growth hormone (GH) was born. A research report published by Dr. Daniel Luhmann in the New England Journal of Medicine showed that men aged 61 to 81 who received subcutaneous injections of growth hormone could increase muscle mass by 8.8% and reduce body fat by 14.4%. These men had increased bone density and thickened skin in their spines. However, such assistance cannot reverse the adverse effects of aging, such as the decline in muscle strength and aerobic capacity. In fact, there is no evidence that these men live longer, are healthier, or enjoy a better quality of life. In addition, 24 to 36% of people who participated in human growth hormone studies also experienced side effects, including swollen feet and ankles, joint pain, carpal tunnel syndrome, and prediabetes.
Large multinational pharmaceutical companies (MNC) still use human growth hormone injection method because liquid/spray human growth hormone is very unstable. If these super multinational corporations with thousands of scientists and billions of dollars in research funding cannot develop a stable growth hormone spray. Human growth hormone is a large-granule peptide (191 amino acids) that is twice the size of the insulin hormone. If big pharmaceutical companies can't develop insulin that can be absorbed under the tongue, how can they do it with human growth hormone? Millions of people with diabetes certainly don't want to take insulin injections every day.
◾️ In addition, after using growth hormone spray, the level of growth hormone will increase; once it increases, can it bring long-term benefits? These suspicions still need to be confirmed. It is worth mentioning that they all prescribe "synthetic" human growth hormone.
Deoxyepiandrosterone (DHEA)
Deoxyepiandrosterone is a weak steroid hormone synthesized mainly from cholesterol in the adrenal cortex.
Marketers tout these hormones as protecting against cancer, heart disease and diabetes, as well as strengthening the immune system, preserving youth, promoting muscle building and eliminating body fat.
After the age of 30, the level of deoxyepiandrosterone in our body will decrease; by the age of 75, the level of deoxyepiandrosterone in the blood will drop to only 20% of the level when we were young. The most common conclusion regarding deoxyepiandrosterone supplementation is that it increases blood deoxyepiandrosterone levels to youthful levels, thereby reducing the adverse effects of the aging process. Many people want to supplement this 6 natural 6 hormone when it is proven to be helpful and ignore its potential harm (just like human growth hormone).
Pharmaceutical companies use chemicals extracted from wild taro to make deoxyepiandrosterone. Its dosage ranges from 10 mg to 2000 mg. Its effects on the healthy aging process and possible side effects are not fully known. However, there are growing concerns about the effects of uncontrolled long-term use of deoxyepiandrosterone at doses of 50 mg or above on body function and overall health. The most common conclusion is that it can reduce the adverse effects of the aging process by increasing blood levels of deoxyepiandrosterone to youthful levels. Many people want to supplement these 6 natural hormones when it is proven to be helpful and ignore the potential harm (just like human growth hormone).
◾️ Androgens converted from deoxyepiandrosterone, such as testosterone, can cause women to grow facial hair and interfere with menstrual function. Like exogenous anabolic steroids, deoxyepiandrosterone lowers HDL cholesterol, thereby increasing the risk of heart disease. Clinicians worry that elevated levels of deoxyepiandrosterone may stimulate other latent prostate tumors or cause benign prostatic enlargement.
Human Growth Hormone Releasing Factor (IGF)
God created man very simply; man becomes complex because of his own actions. Amino acids are not complicated things. A balanced diet helps us get all the amino acids we need. In fact, we consume more protein than our bodies require. There is no doubt that amino acids such as arginine do trigger the release of human growth hormone (HGH) from the pituitary gland. But other fresh protein sources can do the same. The human body is designed to consume a healthy mix of grains and legumes that provide the comprehensive amino acids we need.
◾️Methods to increase growth hormone secretion
- good sleep
- Isotonic/resistance exercise
- lower blood sugar
- Eat a diet with the right amount of protein
Nicotinamide mononucleotide (NMN)
Adult stem cells (ASCs) are a promising source for regenerative medicine, with high proliferation potential and ability to differentiate into various cell types. However, as individuals age, ASCs inevitably undergo cellular senescence, often accompanied by mitochondrial dysfunction. Mesenchymal stem cells (MSCs) are ASCs that have been studied earlier and in depth and have broad basic research and clinical application prospects. Nicotinamide mononucleotide supplementation can improve mitochondrial dysfunction and rescue cellular senescence through the NAD + /Sirt3 pathway in mesenchymal stem cells. However, obtaining a sufficient number of MSCs requires long-term expansion in vitro, which is inevitable It leads to replicative senescence of MSCs, which seriously limits their application in clinical treatment and regenerative medicine. Therefore, developing effective anti-aging drugs and functional foods to delay stem cell aging is a key issue that we urgently need to solve.
NAD+ is a key coenzyme in cellular energy metabolism that can respond adaptively to oxidative stress, participate in metabolic pathways, and affect mitochondrial function. NAD+ levels determine the speed and degree of cellular aging, and NAD+ depletion is closely related to energy metabolism disorders. Nicotinamide mononucleotide (NMN) is the precursor of NAD+ and can alleviate MSC aging caused by NAD+ deficiency. Indeed, NMN can increase mitochondrial NAD + levels, normalize the NAD + /NADH ratio, maintain mitochondrial homeostasis, and thereby restore the function of muscle stem cells in aged mice. Therefore, NMN has broad guiding significance for the exploration of delaying stem cell aging.
◾️ Different from taking stem cells orally, NMN is an enzyme that can improve the energy metabolism of cells. For example, it can increase the recharge battery value of cells and reduce the decay and aging of battery capacity. As for stem cells, they are the original state of any cell in the body. Stem cell intake can improve the body's production of more different stem cells, bringing more young cells in good condition to the body.
◾️ NMN is to increase the energy of body cells and reduce the decline of cells; while stem cells are to add more young cells to the body. There are some relationships between the two and they will affect each other.
Marine protein and collagen
The human dermis is composed of three major elements: collagen, elastin and mucopolysaccharides.
Collagen maintains the integrity of the skin, while elastin provides the elasticity the skin needs. Collagen products sold in cosmetics and health food stores claim to keep skin youthful and age-free. Mucopolysaccharides keep skin supple and hydrated. Anti-aging supplements on the market contain certain marine proteins, including Imedeen and Estime. They are the mucopolysaccharide matrix of the skin. The skin contains "fibroblasts", which naturally produce collagen, elastin and mucopolysaccharides. However, as it ages, its production will gradually slow down.
Placental living cells can activate fibroblasts to produce collagen, elastin and mucopolysaccharides, thereby eliminating wrinkles and restoring skin elasticity and maintaining softness.
