Cliff-like aging
Do you suddenly feel old? "I always thought that people grow old slowly, but in fact, people grow old in an instant," said Haruki Murakami. This quote from "Dance Dance Dance" corresponds to one of the most popular words on the Internet today: cliff-like aging.
When the plot of turning hair white overnight in TV dramas finds scientific basis in reality, when career elites who think they are full of energy begin to realize that they can't stay up late, or suddenly one day they find their nasolabial folds have deepened when they look in the mirror, these signals from the human body have proved that aging can also be cliff-like.
As early as 2019, a study titled Undulating changes in human plasma proteome profiles across the lifespan was published in Nature Medicine, which put forward the view that "aging is not uniform but there are three physiological turning points."
In this study, the authors analyzed 2,925 plasma proteins from 4,263 people (aged between 18 and 95 years old) and found that the plasma proteins in the human body would undergo "oscillating" changes in indicators at roughly three time points, which represent three ages at which "cliff-like aging" occurs: 34, 60 and 78 years old.
Nowadays, as the concept of "cliff-like aging" begins to sweep the Internet, anti-aging has gradually become a modern science that needs to be studied. Looking at the popular anti-aging products today, apart from medical beauty and health care products, most consumers' way of dealing with aging is still limited to the surface.
How does the human body age?
The impact of aging is not only on the surface skin which is the most directly visible, but also causes more deep internal aging.
Face
As a more obvious sign of aging, facial appearance has become the main battlefield in the fight against aging.
Body shape and posture
In addition to skin appearance, changes in body shape and posture are also obvious external features. Of course, in addition to these visible signs, there are also some invisible signs of aging, but they are often ignored by us.
Decreased sensory function
For example, the decline and dullness of the five senses, such as hearing, vision, taste, and smell, is actually due to the gradual aging or even death of the cells that make up the relevant organs. Take the more common hearing loss as an example. It is mainly caused by the loss of hair cells in the inner ear and the imbalance of antioxidant function in the body, which makes us unable to hear other people's speech clearly.
Diabetes, atherosclerosis
For example, the occurrence of common chronic diseases such as diabetes and atherosclerosis is also closely related to cell aging. Because the process of cell aging will cause inflammatory responses, and these chronic inflammations will further lead to cardiovascular problems.
Osteoporosis
There is also osteoporosis, a metabolic bone disease that is extremely common among the elderly, and reduced or disturbed sleep in older people. These subtle physiological changes are manifestations of aging as we age.
How to fight aging?
A. Invasive techniques
Today's anti-aging technologies, such as hyaluronic acid, botulinum toxin, and hyaluronic acid, have allowed modern people to truly achieve "ageless beauty."
Hyaluronic acid (Mesotherapy)
Water injection is to inject hyaluronic acid into the depressions of the skin to stimulate the skin to produce new collagen and maintain the dynamic balance of subcutaneous collagen in the injection site for a long time. It can effectively eliminate various causes of facial skin, such as skin aging problems caused by wrinkles and depressions. It can maintain the dynamic balance of subcutaneous collagen at the injection site, and only about 5% is excreted from the body. In addition, hyaluronic acid can also be used to fill wrinkles and adjust facial tissues.
The ingredients of general hydrating injections on the market are complex, including: hyaluronic acid (Hyaluronic Acid), tranexamic acid (Tranexamic Acid), vitamin C (Vitamin C), botulinum toxin (Botulinum Toxin) collagen (Collagen), complex collagen proliferator, PRP autologous growth factor (Platelet-Rich Plasma), PLT (Platelet-Lyophilized Treatment) and even some emerging ingredients such as exosomes.
Botulinum toxin | Botulinum toxin (BTX)
Commonly known as Botox, it is a type of high-molecular-weight protein neurotoxin produced by Clostridium botulinum when it grows under anaerobic conditions. It mainly inhibits the release of acetylcholine from nerve endings, causing muscle relaxation and paralysis. The medical community first used it as a muscle relaxant in clinical treatment in 1979. Therefore, botulinum toxin injection surgery has certain risks and must be performed by professional dermatologists or facial plastic surgeons. The most famous botulinum toxin company is Botox.
Botox injection into a person's face
Botulinum toxin can eliminate wrinkles or prevent the formation of wrinkles for a period of time by paralyzing relaxed subcutaneous nerves, thus achieving a cosmetic effect. Botulinum toxin is expensive and needs to be re-injected every few months, so it is a luxury that only actresses and celebrity wives can afford all year round.
B. Basic Skin Care Area
A-alcohol, peptide, Bossagra, recombinant collagen, 4 major anti-aging ingredients
Retinoic acid (Retino)
Retino can be translated as retinol, which is abbreviated as A-ol. It is a family transformation of vitamin A, with vitamin A as the main product and anti-wrinkle as the main appeal. It has also always been the leading product of vitamin A ingredients. It can make the skin smoother, reduce fine lines and stimulate collagen production.
A-alcohol advertisement
Peptide
Peptides are naturally occurring small biological molecules that are substances between amino acids and proteins. The English word peptide comes from the Ancient Greek word πέπτω (péptō), which means "to soften, to cook, to digest". Since amino acids are the smallest molecules and proteins are the largest, peptides are short chains composed of amino acid monomers. Active peptides are closely related to nutrition, hormones, enzyme inhibition, immune regulation, antibacterial, antiviral, and antioxidant effects. Peptides can be chemically hydrolyzed from dietary protein. Some known effects include soy and pea peptides reducing inflammation and pain and strengthening muscles around joints. These peptides, also known as protein powders from nutritional supplement companies, are hydrolyzed protein isolates that apply this technology.
Small molecule active peptides
Peptides are sometimes used as cosmetic ingredients because they can promote the proliferation of skin cells. Neuropeptides are peptides that work with nervous tissue. Peptide hormones are peptides that have hormonal effects.
Pro-Xylane
A new anti-aging star, it is a xylose derivative with anti-aging activity, commonly used in cosmetics. Therefore, Bosera facial cream, which costs several thousand yuan per bottle, has become a means for modern people to stay up late. Developed and created by L’Oréal’s Research and Innovation Center, Pro-Xylane is a sugar molecule extracted from beech trees using green chemistry. It works in vitro by stimulating the production of proteoglycans, water-attracting molecules that rebuild the body's skin. It comes from a natural sugar called "xylose" and has multiple functions. Its anti-wrinkle molecules can rebuild the skin's extracellular matrix, reduce deep wrinkles, improve skin dryness and sagging, and thus improve the skin.
Pro-Xylane
Hyaluronic acid
Triple Hyaluronic Acid Vitamin C Serum Product
Hyaluronic acid is a common ingredient in skin care products. Hyaluronic acid is widely present in connective tissue, epithelial tissue and neural tissue. Moisturizing products containing sodium hyaluronate as an active ingredient can be used to relieve dry skin (such as xeroderma caused by atopic eczema). Hyaluronic acid can also be taken orally, enter the human blood, muscles, and accumulate in hard bone tissue, stimulating the skin to produce new collagen.
Hyaluronic acid itself is a natural substance that makes up the human body, so it has no side effects or rejection reactions to the human body. Hyaluronic acid plays an important role in skin moisturizing. Compared with the skin of 20 to 30 years old, the hyaluronic acid content in the human body is 75% at the age of 30 to 40, and only 60% at the age of 40 and above. During the aging process of the skin, the human body will reduce hyaluronic acid, the skin elasticity will decrease, and fine lines will appear. Injecting hyaluronic acid at this time can enhance moisture retention and make the skin moisturized and translucent.
Bakuchiol
Bakuchiol has actually been widely used in herbal therapy for a long time. The seed oil of this leguminous plant can replace the substitute of vitamin A alcohol and achieve an effect similar to skin metabolism to make the skin smooth, fighting the formation of dark spots and repairing the skin. The difference is that it is plant-extracted from leguminous plants grown in East Asia. It can promote the growth of skin collagen, reduce fine lines and wrinkles, and has even been proven to reduce skin damage caused by UV rays.
Stem Cell Anti-Aging
Take stem cell anti-aging, which has been highly sought after in recent years, as an example. In medicine, stem cells are cells that have the properties of unlimited replication and proliferation, and have the characteristics of self-replication, directed development, repair and replacement of damaged cells. Under certain conditions, it can differentiate into a variety of functional cells and has the potential to develop into blood, brain, bones and various organs of the human body.
James Thomson (cell biologist)
C. Eight major tips for fighting diseases of the past year
The first thing is to cultivate good living habits. Health should start from oneself.
The research team at Harvard University revealed eight aspects of life, eating and drinking habits, health, and extending life.
- Constant movement: Helps increase physical ability, protects against chronic diseases.
- Increased intake of fruits, whole grains, reduced intake of red meat, eating and drinking habits: reduced intake of red meat, processed foods, high-fat meat and zero diet, refined starch, can protect against various diseases.
- Non-smoking: Smoking is associated with multiple diseases, including cancer, cardiovascular diseases, etc.
- Excessive drinking: Excessive drinking increases cancer, mental and behavioral disorders, liver disease, and cardiovascular disease.
- Satisfied sleep: Rejuvenate your body and restore your mental health.
- Strength management: Appropriate strength management, travel, etc., to help maintain physical and mental health.
- Good socialization: Social life benefits mental health.
- Avoidance dependents: Reduction of dependents, need to stop self-abuse, etc.
▲ A study by Harvard University lists eight tips to help fight diseases in old age.
However, it is not easy for us urbanites to do this due to various work pressures and other reasons, so we turn to skin care products for solutions.
D. Self-centered cell initiation
Why is it said that returning to the essence of aging must start with caring for our cells? This is because cells are the smallest units of the human body.
The internationally renowned academic journal Nature's definition of aging is also inseparable from cells: "Aging is the process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing cell death, which can be induced by unrepaired DNA damage or other cellular stress."
In fact, the aging of the human body and its organs begins with cells, which has become a consensus in the anti-aging field. That is to say, if the cells are young, the organs they make up are also young, and if the organs are young, the organisms they make up are also young. The human body needs to maintain the youthfulness of cells and their functions in order to achieve anti-aging from the root cause.
For humans, whether it is hair loss and graying, osteoporosis, cognitive decline and memory loss, or even vision deterioration, these are all physical signs of aging that can be perceived directly or indirectly. However, aging at the cellular and molecular levels is often imperceptible to our naked eyes or bodies. It's like a bad apple, the skin may look only slightly aged, but the inside is already deeply eroded.
Returning to the essence of aging, anti-aging at the cellular level
Cell maintenance nutrients
A 2023 study in Cell, a professional journal in the field of life sciences, defined 12 signs of aging at the cellular level. It includes three cluster indicators: microenvironment aging, regulatory imbalance and underlying damage. For example, taking the imbalance regulation index as an example, it includes cell aging, mitochondrial dysfunction, and nutrient sensing disorder.
12 Cell Aging Theories
The 12 major cell aging theories published in the professional journal Cell in 2023
The underlying signs of damage include genomic instability, telomere attrition, epigenetic changes, loss of protein homeostasis and inactivation of macroautophagy. For example, when we feel greater stress, the telomeres that protect our chromosomes may not be able to withstand it, thereby accelerating cell aging.
As consensus has been formed on the aging standards at the cellular level, cell revitalization has become a solution to achieve anti-aging from the cellular source.
After nine years of hard work, Amway developed a "Wisdom System" at the Amway China Chinese Herbal Medicine Research and Development Center in Wuxi, China, which took six years to develop. This system is a technological achievement that combines modern technologies such as big data and AI with traditional wisdom. In 2024, through countless plant raw materials and Chinese medicine DNA intelligent system, five plant ingredients were screened out from more than 50,000 compounds: ellagic acid, gallic acid, rutin, quercetin, and cyanidin galactoside, and mild and safe natural plant extracts were extracted.
2022: Polyphenols in emblica, such as ellagic acid and gallic acid, have anti-aging effects (left)
2023: Among 37 plant molecules, rutin was found to be the most effective in clearing aging cell phenotypes (Medium)
2019: Pomegranate metabolite urolithin can enhance cell and mitochondrial function and thus fight aging (right)
These five phytonutrients are found in high concentrations in more than 600 plants as Chinese herbal raw materials. For example, Dendrobium officinale flowers contain rutin; Sophora japonica contains quercetin and rutin; Aronia berry contains cyanidin galactoside; Pomegranate and Emblica emblica contain ellagic acid and gallic acid.
Ellagic acid
Ellagic acid is a natural phenolic antioxidant found in many fruits and vegetables, including blackberries, strawberries, pomegranates, wolfberries, raspberries, white oak nuts, cranberries, pecans, and other plants. Ellagic acid has antiproliferative and antioxidant properties.
Gallic acid (GA)
It can be found in gallnut, witch hazel, sumac, oak bark, and tea. Aged oolong tea has a higher content of gallic acid. Oolong tea that has been professionally stored for many years tastes better than everyday oolong tea, and it contains more phenolic antioxidants, especially gallic acid (GA). Epigallocatechin gallate (EGCG), a phenolic antioxidant known to promote health, in oolong tea produces powerful gallic acid when oolong tea is aged. This was confirmed by liquid chromatography and mass spectrometry analysis of oolong tea and aged oolong tea.
One of the most notable benefits of gallic acid is its ability to prevent heart failure. There is growing evidence that natural compounds can minimize:
Rutin
Rutin is a flavonoid glycoside found in many plants, including citrus, buckwheat, asparagus, the leaves and petioles of rhubarb, the flowers of Dendrobium officinale, and the flowers and peels of Sophora japonica, fruits and peels (especially citrus fruits such as oranges, grapefruits, lemons and limes), mulberries, ash berries and berries such as cranberries.
Quercetin and rutin are used as vascular protectants in many countries and are components of many multivitamins and herbal remedies.
Quercetin
It is a plant flavonol, a flavonoid compound among polyphenols, and a plant flavonol derived from polyphenol flavonoid compounds. It’s found in many fruits, vegetables, leaves, seeds, and grains; capers, red onions, and kale are common foods that contain high amounts of it. Some studies suggest that quercetin may have anti-inflammatory properties and is a free radical scavenger. Quercetin may help maintain healthy sinus, respiratory, and immune system function, and is being studied for its potential therapeutic benefits. There are preliminary studies on the safety and effectiveness of quercetin for sarcoidosis, asthma, lowering blood pressure in obese patients with hypertension, and improving glucose absorption in diabetes. The combined use of quercetin and resveratrol can inhibit the production of fat cells. Sophora japonica contains rich quercetin and rutin. Sophora japonica (Chinese: 槐) is one of the 50 basic herbs in traditional Chinese medicine. Its fruit has anti-stress and antioxidant effects.
Cyanidin 3-O-galactoside
Cyanidin is one of the most common anthocyanins and is widely found in the flowers, fruits and even stems and leaves of many plants. The main component of black bean seed coat is cyanidin-3-galactoside.
Nutrilite™ iCell Drink
Professor Maria A. Blasco, an authoritative author on telomere anti-aging research, as well as internationally renowned biochemist and 2004 Nobel Prize winner in Chemistry Professor Avram Hershko, molecular biologist and professor at the University of California, Los Angeles David Walker and other top scientists have also conducted further research for Amway Nutrilite in the field of anti-aging. Amway, as a leading health brand deeply engaged in the field of nutrition and health care, uses super products as its fulcrum. In 2024, it launched the Nutrilite Source Revitalizing Drink, which focuses on cell-level care and has the revitalizing effect of natural plant extracts. Perhaps this is the solution that was born for this purpose.
PolyU and Amway (China) establish "Joint Laboratory for Phytonutrients and Aging Research"
The least we can do is to take good care of every cell. Because only when cells have vitality can our organs, tissues and even the human body stay healthy and show better vitality during the irreversible aging process.
Oral stem cell anti-aging
It should be pointed out that at the biological level, it has always been believed that cell aging is irreversible and that humans cannot truly fight against time. This idea of achieving anti-aging from the source of cells and reversing cell aging requires a substance that can be easily absorbed and replenished, and can even be replenished by the body with stem cells, allowing the body to repair and regenerate.
"Uncle Ping", who has business dealings with Jiahong, is pictured at a company in Hong Kong that operates an oral stem cell business in Singapore. In 2019, Uncle Ping developed tracheal and pulmonary dysfunction syndrome due to side effects of vaccines. Through oral stem cells, his condition improved rapidly and he has now recovered.
Due to the regenerative ability of stem cells, many stem cell skin care products have appeared on the market. However, in addition to long-term high investment, safety is also a point that needs to be considered. Taking invasive stem cell skin care products as an example, for consumers, what needs to be considered is the source of the tissues from which these stem cells are obtained, because different sources and individuals may trigger immune rejection reactions, leading to inflammation, tissue damage, etc. At the same time, we also have to consider that the processes of stem cell extraction, culture and infusion will not introduce pathogens and cause infection.
At present, there are stem cell products on the market that can be taken orally. Through high-tech extraction and bioabsorption technology, it is very likely to become a new medical technology. They have started commercial production in some advanced foreign laboratories through live deer fetus extraction technology without killing any animals.
Currently, there are countless cases and real cases that prove that this safe and effective method can restore the body's original functions, and even reverse aging and restore youth. The effect is not only magical, but also makes people unconfident. Currently in the scientific field, this is a major scientific cognition field in the future. This type of product is not sold through the retail level in the market. We are not currently a retailer of this product. For more in-depth understanding, please contact us and we can arrange for a distributor to contact you.
The least we can do is to take good care of every cell. Because only when cells have vitality can our organs, tissues and even the human body stay healthy and show better vitality during the irreversible aging process.
References
- "Undulating changes in human plasma proteome profiles across the lifespan", Nature Medicine, Published: 05 December 2019
- Cell Journal Best of Cell2023, Hallmarks of aging: An expanding universe
- Hong Kong Economic Times - British registered dietitian Wong Siu-cheung - Survey reveals Hong Kong people's concerns about "longevity with illness" Five natural plant extracts help fight aging (Dendrobium officinale contains rutin, Aronia berries are rich in cyanidin 3-O-galactoside, Olea europaea and pomegranates contain ellagic acid and gallic acid, Sophora japonica flowers are rich in quercetin and rutin) and delay cell aging
